Advanced ProtocolPerformanceMuscle & Growth

IGF-1 LR3

Insulin-Like Growth Factor 1 Long R3

A long-acting analog of IGF-1 with research into muscle development, tissue repair, fat metabolism, and cellular growth.

Researched Wellness Applications

✓ Muscle protein synthesis and development support

✓ Fat metabolism and body composition support

✓ Tissue repair and cellular growth signaling

✓ Recovery and performance enhancement research

Assessment Options

$310

No subscription · Physician reviewed

Lab panel required prior to prescribing. Your physician will confirm required labs during the review process.

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Physician review required · Ships in 48h after approval · All 50 states

Split payments available with affirm — 0% interest options

What Is It?

IGF-1 LR3 explained simply

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is an analog of IGF-1, the natural hormone that mediates many of growth hormone's effects on the body. The LR3 modification extends its half-life from minutes to approximately 20-30 hours, making it significantly more potent and longer-acting than natural IGF-1.

IGF-1 is a key mediator of tissue growth and repair, particularly for muscle, bone, and neural tissue. Research has explored its applications in muscle hypertrophy, recovery, fat loss, and even neuroprotection. Due to its potency, IGF-1 LR3 is considered an advanced protocol that requires careful physician oversight.

20-30h

Extended half-life vs natural IGF-1

Physician

Oversight strongly recommended

Mechanism

How IGF-1 LR3 works

Primary Mechanism

IGF-1 LR3 binds to IGF-1 receptors (IGF1R), a tyrosine kinase receptor, triggering PI3K-Akt and MAPK signaling cascades. These pathways regulate cell growth, survival, differentiation, and metabolism. The LR3 modification reduces binding to IGF-binding proteins, extending circulating half-life and increasing tissue availability.

Research Context

The research on IGF-1 LR3 spans multiple decades and institutions. Studies have examined its effects in preclinical and clinical settings. Our Education Center contains curated summaries of the most relevant published literature. As with all research peptides, individual results vary and the evidence base continues to evolve.

Administration

The appropriate administration method, dosage, and protocol for IGF-1 LR3 is determined through the BRAVO1 physician review process based on your individual health profile and wellness goals. Do not self-administer any peptide protocol without physician oversight.

FAQ

Questions about IGF-1 LR3

Appropriateness is assessed on an individual basis through our physician review process. Generally, IGF-1 LR3 is researched in the context of the wellness applications listed above. Our physician will review your specific health history and goals before determining appropriateness for your situation.

The administration method for IGF-1 LR3 is determined through the physician review process based on your specific protocol. Detailed administration instructions are provided with every order, and our support team is available to answer any questions.

The appropriateness of combining IGF-1 LR3 with other protocols is evaluated during the physician review process. Our reviewing physician considers your complete health picture and any concurrent protocols when making their determination.

All BRAVO1 orders ship within 48 hours of physician approval. Orders are shipped from our temperature-controlled facility and are available for delivery to all 50 states. You will receive a tracking confirmation as soon as your order dispatches.