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NAD+

Nicotinamide Adenine Dinucleotide

A critical coenzyme found in every cell of your body. NAD+ declines with age — and restoring it has become one of the most researched areas in longevity science.

Researched Wellness Applications

✓ Cellular energy production (ATP synthesis)

✓ DNA repair and genomic stability

✓ Sirtuin activation and longevity pathways

✓ Metabolic function and mitochondrial health

✓ Neurological health support

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What Is It?

NAD+ explained simply

Imagine your cells as factories. NAD+ (Nicotinamide Adenine Dinucleotide) is the fuel that keeps those factories running. It's a coenzyme — a molecule that helps enzymes do their jobs — and it's involved in hundreds of metabolic reactions throughout your body.

The problem? NAD+ levels decline naturally as we age. By the time we're 50, we may have less than half the NAD+ we had at 20. Researchers have linked this decline to many hallmarks of aging — reduced energy, declining cognitive function, slower recovery, and increased susceptibility to metabolic dysfunction.

This has made NAD+ supplementation and therapy one of the most researched areas in longevity medicine. Scientists like Dr. David Sinclair at Harvard have dedicated significant research efforts to understanding how restoring NAD+ levels may support healthspan and lifespan.

500+

Peer-reviewed studies

~50%

Decline by age 50

Every

cell in your body

Mechanism

How NAD+ works in your body

Mitochondrial Energy Production

NAD+ is essential to the electron transport chain — the process by which your mitochondria generate ATP (cellular energy). Without adequate NAD+, this process slows, reducing the energy available to every cell in your body.

Sirtuin Activation

NAD+ is a required cofactor for sirtuins — a family of proteins often called "longevity genes." Sirtuins regulate gene expression, DNA repair, inflammation, and stress responses. Higher NAD+ levels have been associated with increased sirtuin activity in research models.

DNA Repair via PARP Enzymes

PARP enzymes consume NAD+ to repair damaged DNA. As DNA damage accumulates with age, PARP activity increases, depleting NAD+ further. Maintaining NAD+ levels may support the body's DNA repair capacity.

Cellular Metabolism & Signaling

Beyond energy production, NAD+ participates in cellular signaling pathways that regulate inflammation, stress responses, circadian rhythms, and apoptosis — all of which have implications for healthy aging.

FAQ

Common questions about NAD+

NAD+ can be administered via IV infusion, subcutaneous injection, intramuscular injection, or as an oral supplement (though oral bioavailability is lower). The specific protocol and administration method are determined through the physician review process based on your goals and health status.

Individual responses vary. Some people report increased energy and mental clarity relatively quickly, while other benefits — particularly those related to longevity and cellular health — are believed to accumulate over time. NAD+ therapy is generally viewed as a long-term wellness investment rather than an immediate-effect solution.

NAD+ is generally well-tolerated. Common transient side effects may include flushing, nausea, or fatigue, particularly with IV infusions. These are typically manageable and dose-dependent. Your reviewing physician will assess your specific situation and provide guidance on what to expect.

NAD+ is frequently used alongside other longevity-focused protocols. The appropriateness of combinations is assessed during the physician review. Common pairings in the research literature include NAD+ with Epitalon and Glutathione.

NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are precursors to NAD+ — meaning the body converts them into NAD+. They are different molecules with different delivery characteristics and research profiles. NAD+ direct supplementation bypasses the conversion step, but each form has its own research base and administration considerations.