BRAVO1's Cognitive Mixed Vial is a physician-formulated stack combining three complementary neuropeptides that address cognitive health from different angles simultaneously — neuroprotection, neuroplasticity, and neurochemical balance. Together they produce a synergistic effect that no single peptide can achieve alone.
CNS
Central nervous system
PinealonGlu-Asp-Arg · Tripeptide
Pinealon is a short tripeptide (Glu-Asp-Arg) originally isolated from pineal gland tissue. Research suggests it has strong neuroprotective properties — reducing oxidative stress in neural tissue and modulating gene expression associated with aging in the brain. It has also been studied for its potential role in supporting circadian rhythm regulation and improving sleep architecture. Pinealon may be particularly relevant for age-related cognitive decline and neuroprotective protocols.
PE22-28BDNF Fragment · Neurotrophin
PE22-28 is a truncated fragment of BDNF (Brain-Derived Neurotrophic Factor) that selectively activates the TrkB receptor — the primary receptor through which BDNF promotes neuroplasticity, synaptic strengthening, and mood regulation. By mimicking BDNF signaling at the receptor level, PE22-28 supports long-term potentiation (LTP), memory encoding, and has been studied for antidepressant effects in preclinical models. It is notably being explored as a faster-acting, more targeted alternative to conventional approaches to treatment-resistant depression.
SelankTuftsin Derivative · GABAergic
Selank is a synthetic analog of the immunomodulatory peptide tuftsin, developed in Russia and widely studied for its anxiolytic and nootropic effects. It modulates GABA-A receptor sensitivity and BDNF expression, producing calming effects without sedation or dependence — making it distinct from benzodiazepines. Selank also supports immune function and has been studied for its effects on serotonin, dopamine, and enkephalin systems. It complements both Pinealon and PE22-28 by reducing the background stress and anxiety that impair cognitive performance.
