IntermediateLongevityCellular Energy

SS-31

Elamipretide · MTP-131

A mitochondria-targeted tetrapeptide designed to penetrate the inner mitochondrial membrane, reduce oxidative stress, and restore cellular energy production — studied for longevity, cardiac function, and age-related decline.

Researched Wellness Applications

✓ Mitochondrial function & cellular energy restoration

✓ Oxidative stress reduction

✓ Cardiovascular & cardiac muscle support

✓ Renal (kidney) protection

✓ Age-related fatigue & muscle function

Assessment Options

$299

No subscription required · Physician reviewed

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Physician review required · Ships in 48h after approval · All 50 states

Split payments available with affirm — 0% interest options

What Is It?

SS-31 explained simply

SS-31 (also known as Elamipretide or MTP-131) is a synthetic tetrapeptide engineered specifically to target and protect the inner mitochondrial membrane. Mitochondria are the powerhouses of every cell — when they decline, so does your energy, recovery, and resilience. SS-31 was designed to address that decline at its source.

Unlike most antioxidants that act broadly, SS-31 accumulates selectively within mitochondria — reaching concentrations up to 1,000× higher inside the mitochondria than in surrounding tissue. This targeted action allows it to stabilize cardiolipin, a critical phospholipid that maintains the structural integrity and efficiency of the inner mitochondrial membrane.

Amino acids (tetrapeptide)

1000×

Mitochondrial concentration

Subcutaneous injection

Mechanism

How SS-31 works

Cardiolipin Stabilization

SS-31 binds selectively to cardiolipin — a phospholipid exclusive to the inner mitochondrial membrane. Cardiolipin is critical for the efficient function of the electron transport chain. As we age or experience metabolic stress, cardiolipin oxidizes and the mitochondrial membrane becomes dysfunctional. SS-31 stabilizes cardiolipin and restores electron transport efficiency, directly improving ATP (energy) output.

Reactive Oxygen Species (ROS) Control

Mitochondrial dysfunction is closely tied to elevated reactive oxygen species — a form of oxidative stress that damages cellular structures. SS-31's mechanism reduces electron leak in the respiratory chain, cutting off the primary source of mitochondrial ROS production at the root rather than simply scavenging free radicals downstream.

Clinical & Research Context

SS-31 (Elamipretide) has been studied in clinical trials for heart failure, Barth syndrome, and primary mitochondrial myopathy. Research has also explored applications in age-related muscle decline (sarcopenia), renal ischemia, and neurodegenerative conditions. The peptide has an extensive body of published research across cardiovascular, metabolic, and longevity science. Our Education Center contains curated summaries of key literature.

Administration

SS-31 is typically administered via subcutaneous injection. The appropriate dosage, frequency, and protocol is determined through the BRAVO1 physician review process based on your individual health profile and wellness goals. Do not self-administer any peptide protocol without physician oversight.

FAQ

Questions about SS-31

SS-31 is typically explored by individuals focused on longevity, cellular energy optimization, and cardiovascular wellness. Appropriateness is assessed on an individual basis through our physician review process, which evaluates your specific health history and goals before determining suitability for this protocol.

SS-31 is administered via subcutaneous injection. Detailed administration instructions — including site selection, technique, and frequency — are provided with every order. Our support team is also available to answer any questions about the process.

The appropriateness of combining SS-31 with other protocols is evaluated during the physician review process. SS-31 is sometimes used alongside longevity-focused protocols like NAD+ or GHK-Cu, but your reviewing physician considers your complete health picture before making any recommendation.

All BRAVO1 orders ship within 48 hours of physician approval, from our temperature-controlled facility. Orders are available for delivery to all 50 states. You'll receive a tracking confirmation as soon as your order dispatches.

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Start the physician review process for SS-31. Ships within 48 hours of approval to all 50 states.

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Physician Reviewed

Ships to All 50 States

48-Hour Fulfillment

LegitScript Certified

Licensed Pharmacy Partner

Partner Pharmacy

PerfectRx

Phone(866) 866-6806

Emailinfo@perfectrx.com

Address5810 Long Prairie Rd
Flower Mound, TX 75028

Service Availability

United States

Serving all 50 states. Products are fulfilled through our licensed compounding pharmacy partner and shipped directly to patients following physician approval.

Provider Licensure Disclosures

Arora Health and Aesthetics · Dr. Sean Arora

Vermont

License 042.0016085-COMP Expires 11/31/2026

Rhode Island

License MD20370 Expires 06/30/2026

Massachusetts

License 1018420 Expires 07/20/2027