IntermediateBody CompositionLongevity

Tesamorelin

GHRH Analogue · Egrifta (FDA-approved form)

A synthetic analogue of Growth Hormone-Releasing Hormone (GHRH) with an extensive clinical research record, including FDA approval. Studied for visceral fat reduction, growth hormone optimization, body composition improvement, and metabolic health.

Researched Wellness Applications

✓ Visceral (abdominal) fat reduction

✓ Growth hormone & IGF-1 optimization

✓ Lean muscle preservation & body recomposition

✓ Metabolic health & lipid profile

✓ Energy, recovery & sleep quality

Assessment Options

$299

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Physician review required · Ships in 48h after approval · All 50 states

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What Is It?

Tesamorelin explained simply

Tesamorelin is a stabilized synthetic analogue of Growth Hormone-Releasing Hormone (GHRH) — the hypothalamic signal that instructs the pituitary gland to release growth hormone (GH). Unlike direct GH injections, Tesamorelin works by amplifying the body's natural pulsatile GH secretion rather than bypassing it, resulting in a more physiologically appropriate GH response.

Its FDA-approved form (Egrifta) was developed for HIV-associated lipodystrophy and has produced some of the most rigorous clinical data on visceral fat reduction of any peptide in this class. That research base makes Tesamorelin one of the most evidence-supported GHRH analogues for body composition applications outside of a disease-state context.

In the wellness and longevity space, Tesamorelin is valued for its ability to raise GH and IGF-1 levels, support visceral fat loss, improve sleep quality, and enhance recovery — all while preserving the feedback mechanisms that prevent supraphysiological GH excess.

FDA

Approved clinical history

GH / IGF-1

Primary axes elevated

Subcutaneous injection

Mechanism

How Tesamorelin works

GHRH Receptor Activation

Tesamorelin binds to GHRH receptors on pituitary somatotroph cells, stimulating the synthesis and pulsatile release of endogenous growth hormone. Because it works through the body's own regulatory feedback mechanisms, it avoids the blunted feedback and receptor desensitization associated with exogenous GH administration.

Visceral Fat & Body Composition

Clinical trials demonstrated statistically significant reductions in visceral adipose tissue (VAT) — the metabolically active abdominal fat linked to insulin resistance and cardiovascular risk. This effect appears to be mediated through elevated GH and IGF-1 acting on lipolytic pathways in visceral fat tissue. Lean mass is generally preserved or improved concurrently.

Metabolic & Longevity Effects

Beyond body composition, elevated GH and IGF-1 from Tesamorelin are associated with improved lipid profiles, enhanced protein synthesis, better sleep architecture (particularly slow-wave sleep when GH is naturally secreted), and improved energy levels and recovery. These effects align closely with the goals of longevity-focused peptide protocols.

Administration

Tesamorelin is administered via subcutaneous injection, typically once daily in the evening to align with the natural nocturnal GH pulse. The appropriate dosage and protocol duration is determined through the BRAVO1 physician review process based on your individual health profile and goals.

FAQ

Questions about Tesamorelin

Tesamorelin is commonly explored by individuals focused on body recomposition — particularly visceral fat reduction — as well as those interested in GH optimization for longevity, recovery, and metabolic health. Appropriateness is assessed individually through our physician review process.

Both are GH-stimulating protocols, but with different mechanisms. Tesamorelin is a pure GHRH analogue — it stimulates GH through GHRH receptors. CJC-1295/Ipamorelin combines a GHRH analogue with a GHRP (ghrelin mimetic), which stimulates GH through two complementary pathways. Tesamorelin has a stronger evidence base from clinical trials, particularly for visceral fat. The right choice depends on your goals and health profile, assessed during physician review.

Compatibility with other protocols is evaluated during the physician review process. Tesamorelin is sometimes used alongside metabolic or body composition protocols, but stacking GH-axis peptides requires careful consideration, which your reviewing physician will address.

All BRAVO1 orders ship within 48 hours of physician approval from our temperature-controlled facility. Delivery is available to all 50 states. You'll receive tracking confirmation as soon as your order dispatches.